Antidiarrheal and Antioxidant Activities of the Aerial Parts of Caralluma dalzielii N. E. Brown
نویسندگان
چکیده
Pharmacognosy Research,2022,14,1,82-88.DOI:10.5530/pres.14.1.12Published:December 2021Type:Original ArticleAuthors:Chinenye J. Ugwah-Oguejiofor, Halilu E. Mshelia, Junaidu Bello, Isah Inuwa, and Abdullahi Sulaiman Author(s) affiliations:Chinenye Ugwah- Oguejiofor1,*, Mshelia2,3, Bello1, Inuwa1, Sulaiman1 1Department of Pharmacology Toxicology, Faculty Pharmaceutical Sciences Usmanu Danfodiyo University Sokoto, NIGERIA. 2Department Pharmacy, Cyprus International University, Nicosia, Mersin 10, TURKEY. 3Department Ethnopharmacy, Sciences, P.M.B. 2346 Abstract:Background: Caralluma dalzielii N.E. Brown is commonly referred to as “Karan massalanci” in the Northwest Nigeria where it used treating several ailments including pain, diarrhea stomach issues. Objectives: This study was aimed investigate antidiarrheal antioxidant activities aqueous aerial parts extract dalzielii. Materials Methods: The (CDE) (100, 200 400 mg/kg) evaluated for properties against gastrointestinal motility, castor oil-induced prostaglandin-E2 (PGE2) enteropooling models Wistar rats. Its were studied by determining total phenolic content (TPC) using Folin-Ciocalteu reagent, its free radical scavenging activity 1, 1-Diphenyl-2-Picrylhydrazyl (DPPH) ferric reducing power (FRAP) assays potassium ferrocyanide chloride methods. Ascorbic acid reference. Spasmolytic effect isolated rabbit jejunum preparations an organ bath experiment acetylcholine (ACh). Results: CDE significantly (p<0.05) reduced transit charcoal meal number diarrheal feces animals. determined be 36.67±3.33 mg GAE/g. IC50 value 63.44 mg/mL calculated DPPH assay. FRAP found increase concentration increased. inhibited acetylcholine-induced contraction a dependent manner with complete inhibition at 20.48 extract. Conclusion: possesses which may related antimotility, antispasmodic properties. Keywords:Antioxidant, Antispasmodic, dalzielii, Gastrointestinal Rabbit jejunum.View:PDF (543.04 KB) Full Text
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ژورنال
عنوان ژورنال: Pharmacognosy Research
سال: 2021
ISSN: ['0974-8490', '0976-4836']
DOI: https://doi.org/10.5530/pres.14.1.12